" High value-added chemicals and BIoreSIns from alGae biorefineries produced from CO2 provided by industrial emissions "


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Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides

The relevance of microalgae biotechnology for producing high-value compounds with biomedical application, such as polysaccharides, has been increasing. Despite this, the knowledge about the composition and structure of microalgae polysaccharides is still scarce. In this work, water-soluble polysaccharides from Nannochloropsis oculata were extracted, fractionated, structurally analysed, and subsequently tested in terms of immunostimulatory activity. A combination of sugar and methylation analysis with interaction data of carbohydrate-binding proteins using carbohydrate microarrays disclosed the complex structural features of the different polysaccharides. These analyses showed that the water-soluble polysaccharides fractions from N. oculata were rich in (?1?3, ?1?4)-glucans, (?1?3)-, (?1?4)-mannans, and anionic sulphated heterorhamnans. The immunostimulatory assay highlighted that these fractions could also stimulate murine B-lymphocytes. Thus, the N. oculata water-soluble polysaccharides show potential to be further explored for immune-mediated biomedical applications.

» Author: Carolina O. Pandeirada, Élia Maricato, Sónia S. Ferreira, Viviana G. Correia, Benedita A. Pinheiro, Dmitry V. Evtuguin, Angelina S. Palma, Alexandra Correia, Manuel Vilanova, Manuel A. Coimbra, Cláudia Nunes

» Reference: 10.1016/j.carbpol.2019.06.001

» Publication Date: 04/06/2019

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This project has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n [613680].

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